Understanding Research on Smoking Cessation Methods, including Vaping

This blog is provided for general educational purposes only and is not intended to promote or advertise any therapeutic good

Quitting smoking can be approached in different ways, including behavioural support, nicotine replacement therapy (NRT), prescription medications, and, in certain circumstances, prescription nicotine vaping products.

Research in this area continues to evolve. One widely referenced source of evidence is Cochrane, an independent global network that produces systematic reviews used to inform healthcare decision-making.

What did the Cochrane review examine?
A recent Cochrane Review analysed 78 studies involving more than 22,000 participants. Of these, 40 were randomised controlled trials (RCTs), which are commonly used in evaluating safety and effectiveness in healthcare.

  • The review examined two primary outcomes:
  • Rates of smoking cessation lasting six months or longer
  • Reported side effects and adverse events associated with the interventions studied

Systematic reviews such as this are designed to assess the overall body of evidence and identify patterns across multiple studies.

Findings on Smoking Cessation Outcomes
The review reported that nicotine e-cigarettes were associated with higher quit rates compared with some other cessation approaches in the studies analysed. However, results varied across trials and follow-up periods were limited.

Across the included studies, follow-up extended up to two years. While some evidence suggested improved quit rates in certain comparisons, the authors noted that the overall number of long-term studies remains limited.

It is important to interpret findings in the context of evolving research and differing study designs.

Reported Side Effects and Safety Considerations
The review did not identify clear evidence of serious harm within the duration of the included studies (up to two years). Reported short-to-medium term side effects included:

  • Throat or mouth irritation
  • Headache
  • Cough
  • Nausea

Some participants also reported dizziness, increased heart rate, shortness of breath, and sleep disturbances. In many cases, these effects reduced over time.

However, long-term safety data beyond two years is currently limited, and further research is needed to better understand potential long-term cardiovascular and respiratory impacts.

What Does This Mean for Individuals Considering Quitting?
There is no single cessation approach that works for everyone. First-line smoking cessation therapies in Australia typically include:

  • Nicotine replacement therapy (patches, gum, lozenges)
  • Prescription medications
  • Behavioural support

Nicotine vaping products are prescription-only in Australia and are regulated therapeutic goods. Their use should be considered in consultation with a qualified healthcare professional.

When deciding on a cessation strategy, individual medical history, previous quit attempts, and personal circumstances should all be considered.

Disclaimer
Nicotine vaping products are prescription-only medicines in Australia and are regulated therapeutic goods.They are not approved as first-line smoking cessation therapies. They may be considered by a healthcare professional in certain circumstances, typically where other first-line smoking cessation therapies have not been successful.

Evidence regarding long-term safety and effectiveness remains limited, and further research is ongoing. Vaping is not risk-free, and dual use (continuing to smoke while vaping) is not recommended.

Decisions about smoking cessation strategies should be made in consultation with a qualified healthcare professional, who can assess individual health history and provide appropriate guidance.

DISCLAIMER: There are a number of ways to quit smoking. We have a range of tools that may help with smoking cessation such as nicotine patches, gums and vaping products. Vaping products, used as second-line tools may be useful for those who have not successfully quit smoking using traditional methods.  

It’s important to acknowledge there’s limited available evidence on the efficacy, safety or long-term health effects of nicotine vaping products. There are potential side effects associated with vaping. Long-term vaping and dual-use (smoking and vaping concurrently) is not recommended and should be avoided.  Regular review and monitoring by your regular GP is advised along your smoking cessation journey.

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